Ketanserin treatment in essential hypertension.
نویسندگان
چکیده
منابع مشابه
Ketanserin in essential hypertension: a double-blind, placebo-controlled study.
The antihypertensive effect of the selective serotonin antagonist ketanserin was examined in a double-blind, placebo-controlled, parallel group study in 20 patients with essential hypertension. After 7 weeks treatment with ketanserin (mean dose 71 mg/d) there was a significant fall of both systolic and diastolic blood pressure, as compared to placebo, with a peak effect of 19.1/9.1 mmHg lying (...
متن کاملHaemodynamic and humoral responses to chronic ketanserin treatment in essential hypertension.
Ketanserin (120 mg/day) or placebo was given orally to 14 patients with mild to moderate essential hypertension according to a double blind crossover protocol, each treatment period lasting six weeks. Resting intra-arterial pressure in the recumbent position was reduced from 150/84 to 141/77 mm Hg; the hypotensive effect persisted throughout an uninterrupted graded exercise test to the point of...
متن کامل5-HT, alpha-adrenoceptors, and blood pressure. Effects of ketanserin in essential hypertension and autonomic insufficiency.
The serotonin (5-hydroxytryptamine, 5-HT) antagonist, ketanserin, has a high affinity for 5-HT2-receptors but it also binds to alpha 1-adrenoceptors. The compound (10 mg i.v.) lowered mean arterial pressure by 22% +/- 2% (mean +/- SEM, p less than 0.001) in 30 patients with essential hypertension. Measurements of heart rate, cardiac output, cardiac filling pressures, forearm blood flow, renal b...
متن کاملEssential hypertension : part II: treatment.
The goal of antihypertensive treatment is to reduce overall CVD risk and thus its morbidity and mortality rates. In any given patient, the decision to begin treatment is governed by the risk of CVD, which is determined by the magnitude of the BP elevation and the presence or absence of target organ disease and/or additional CVD risk factors. Recent consensus committees, including JNC VI and the...
متن کاملTreatment of hyperuricemia in essential hypertension.
Treatment of Hyperuricemia in Essential Hypertension To the Editor: The 2 recent articles linking an elevated serum uric acid level with an increased risk of developing hypertension are of great interest.1,2 The application of the key finding in these 2 studies, that is, a graded increase in risk of developing essential hypertension based on the serum uric acid level, is likely to be more far r...
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ژورنال
عنوان ژورنال: Heart
سال: 1984
ISSN: 1355-6037
DOI: 10.1136/hrt.52.3.359